IGF-1

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Also known as: Somatomedin C
Formal name: Insulin-like Growth Factor-1
Related tests: Growth Hormone (GH), Glucose, Glucose Tolerance Test, GH Stimulation Test

At a Glance

Why Get Tested?

To identify diseases and conditions caused by deficiencies and overproduction of growth hormone (GH), to detect disease of the pituitary gland, and to monitor the effectiveness of growth hormone replacement treatment

When to Get Tested?

As part of an evaluation of pituitary function;
1. when you are growing more slowly than normal, have short stature, have delayed development (in children) or decreased bone density, reduced muscle strength, and increased lipids (in adults), all of which suggest insufficient GH and IGF-1 production
2. when you have symptoms of gigantism (in children) or acromegaly (in adults) that suggest excess GH and IGF-1 production
3. during and after treatment for GH abnormalities

Sample Required?

A blood sample taken from a vein in your arm

Test Preparation Needed?

In general, no test preparation is needed; however, since this test may be performed at the same time as others, fasting for at least 12 hours may be required.

The Test Sample

What is being tested?

The insulin-like growth factor-1 (IGF-1) test is an indirect measure of the average amount of growth hormone (GH) being produced by the body. IGF-1 and GH are peptide hormones which are small proteins made up of a small chain of amino acids. IGF-1 and GH are vital for normal bone and tissue growth and development. GH is produced by the pituitary gland, a grape-sized gland which sits at base of the brain behind the bridge of your nose. GH is secreted into the bloodstream in pulses throughout the day and night with peaks that occur mostly during the night. IGF-1 is produced in response to GH stimulation and mainly comes from the liver with a little from muscles. It mediates many of the actions of GH, stimulating the growth of bones and other tissues and increasing the production of muscle mass. IGF-1 excesses and deficiencies mirrors those of GH , but its level does not fluctuate during the day as does GH which makes it a useful indicator of average GH levels.

Like GH, IGF-1 levels are normally low in early childhood, increase gradually during childhood, peak during puberty, and then decline in adult life. Deficiencies in GH and IGF-1 may be caused by conditions such as hypopituitarism or by the presence of a non-GH-producing pituitary tumour that damages hormone-producing cells. Deficiencies in IGF-1 also occur where there is a lack of responsiveness to GH. This insensitivity may be primary (genetic) or secondary as a consequence of conditions such as  malnutrition and chronic diseases.

Deficiencies early in life can inhibit bone growth and overall development and can result in a child with a shorter than normal stature. In adults, decreased production can lead to low bone densities, less muscle mass, and altered lipids.

Excess GH and IGF-1 can cause abnormal growth of the skeleton and other signs and symptoms characteristic of gigantism and acromegaly. In children, gigantism causes bones to grow longer, resulting in a very tall person with large feet and hands. In adults, acromegaly causes bones to thicken and soft tissues, such as the nose, to swell. Both conditions can lead to enlarged organs, such as the heart, and to other complications such as type 2 diabetes, increased cardiovascular disease risk, high blood pressure, arthritis, and a decreased life span. The most common reason for the pituitary to secrete excessive amounts of GH is a GH-producing pituitary tumour (usually benign). Frequently, the tumour can be surgically removed and/or treated with drugs or radiation. In most cases, this will cause GH and IGF-1 levels to return to normal or near normal levels.

How is the sample collected for testing?

A blood sample is collected by inserting a needle into a vein in your arm.

NOTE: If undergoing medical tests makes you or someone you care for anxious, embarrassed, or even difficult to manage, you might consider reading one or more of the following articles: Coping with Test Pain, Discomfort, and Anxiety, Tips on Blood Testing, Tips to Help Children through Their Medical Tests, and Tips to Help the Elderly through Their Medical Tests.

Another article, Follow That Sample, provides a glimpse at the collection and processing of a blood sample and throat culture.

Is any test preparation needed to ensure the quality of the sample?

In general, no test preparation is needed; however, since this test may be performed at the same time as others, fasting for at least 12 hours may be required.

The Test

Common Questions

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.