What is it? Cancer of the cervix (cervical cancer) is caused by the uncontrolled growth of cells in the cervix. The cervix is the narrowed bottom portion of a woman’s uterus. Shaped like a cone, it connects the upper portion of the uterus to the vagina and is the "gateway" of the birth canal.
Cervical cancer begins slowly, with precancerous changes in the cells lining the inside or outside of the cervix; these changes are termed “dyskaryotic cells” if detected on a smear or “cervical intraepithelial neoplasia (CIN)” if detected histologically. If left untreated, CIN may progress to invasive cancer.
About 80-90% of cervical cancers are squamous cell carcinomas, occurring in the flat squamous cells that cover the outside of the cervix. Most other cases are adenocarcinomas, rising from mucus-producing gland cells of the inner endocervix (the opening of the cervix). A few cervical cancers are mixtures of both types.
With early detection, cervical cancer is usually easily treatable. Left unchecked, however, it is almost always fatal. Given time, the cervical cancer can spread (metastasise) to the rest of the uterus, the bladder, the rectum, and the abdominal wall. Eventually, it reaches the pelvic lymph nodes and metastasises. Cervical cancer cells can then invade other organs throughout the body.
Invasive cervical cancer was once a common disease in the United Kingdom. Since the introduction of the
Papanicolaou (Pap) smear, a screening tool that allows the detection of cancerous and precancerous changes in the cervix, rates of cervical cancer in the U.K. and other industrialised nations have dropped by as much as 70%. In developing nations without screening programmes, however, cervical cancer is still a very serious concern. Cervical cancer continues to be the second most common type of cancer in women worldwide (after
breast cancer).
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