Lymphoma

Overview
Signs and Symptoms
Types
Staging
Testing
Treatment
TABLE

The following table illustrates the two most commonly used classifications plus an older classification. Because of differences in how the lymphomas are described, there is not a one-to-one comparison between the systems, and a single disease could be known by multiple names.

Comparison of Some Non-Hodgkin Lymphoma Classifications
Note: These classifications cannot always be compared

NCI* (Working   Formulation) (Older Classification)

REAL**

WHO*** Classification

B cell lineage/NHL

Mature B cell     lymphoma

Low grade lymphoma    Small lymphocytic lymphoma
Small lymphocytic lymphoma (plasmacytoid)

Follicular lymphoma (small cleaved cell, large cell, mixed cell)

High Grade lymphoma Diffuse lymphoma (small cleaved, large, mixed cell) Diffuse immunoloblastic lymphoma
Burkitt Lymphoma
Burkitt-like Lymphoma Lymphoblastic lymphoma

B-cell chronic lymphocytic leukaemia       Lymphoplasmacytic lymphoma
Nodal and extranodal marginal B-cell lymphoma

Follicular Center, grades I, II, and III lymphoma

Mantle Cell lymphoma

B cell CLL / SLL

Splenic marginal zone B-cell lymphoma Extranodal marginal B cell lymphoma

Follicular lymphoma

Mantle cell lymphoma

Diffuse large B-cell lymphoma

Burkitt’s lymphoma

T and NK Cell Neoplasms

T and NK Cell Neoplasms

Mature T cell lymphoma

Small lymphocyte lymphoma

Mycosis Fungoides

Diffuse lymphoma (small cleaved, large, mixed cell)

Large cell immunoblastic lymphoma

Adult T cell lymphoma

Mycosis fungoides (Sézary Syndrome)

Anaplastic large cell lymphoma not otherwise characterized

Immunoblastic T cell lymphoma

Langerhans cell histiocytosis

Langerhans cell sarcoma

Interdigitating dendritic cell sarcoma/tumor

Follicular dendritic cell sarcoma/tumor

Dendritic cell sarcoma, not otherwise specified

* NCI = National Cancer Institute

** REAL = Revised European American Lymphoma

*** WHO = World Health Organization